Research-backed supplements discussed in Your PCOS Playbook — curated to help you cut through the noise and find what may actually help.
The core supplements with the strongest research base for PCOS — a good starting point for most women.
The most researched supplement for PCOS. Supports insulin signaling, ovarian function, and cycle regularity. The 40:1 ratio of myo- to d-chiro-inositol mirrors the body's natural ratio.
Shop on Amazon →Most women with PCOS are deficient. Supports insulin sensitivity, ovarian function, mood, and bone health. Take with K2 and magnesium for best absorption and effectiveness.
Shop on Amazon →Activates AMPK to improve insulin sensitivity and glucose metabolism. Sometimes called "nature's metformin." Requires doctor approval before use — do not combine with diabetes medications without guidance.
Shop on Amazon →Enhances insulin receptor function to improve glucose tolerance and blood sugar stability. A well-tolerated option for supporting metabolic health in PCOS.
Shop on Amazon →Chronic low-grade inflammation is a hallmark of PCOS. These supplements target inflammation at the cellular level.
Blocks the NF-kB inflammatory pathway. Improves insulin sensitivity and supports liver function. Must include piperine (BioPerine) for absorption — without it, curcumin passes through without effect.
Shop on Amazon →Direct anti-inflammatory agent. Supports mood, cardiovascular health, and hormone balance. Look for third-party tested products in triglyceride form for best absorption.
Shop on Amazon →Precursor to glutathione, your body's master antioxidant. Supports ovulation, reduces inflammation, and aids liver detoxification. One of the most versatile supplements for PCOS.
Shop on Amazon →Polyphenol that reduces inflammation, improves insulin sensitivity, and has anti-androgenic properties. Found in grape skins and available as a concentrated supplement.
Shop on Amazon →Supports cellular energy production and egg quality. Particularly relevant for fertility. Choose the ubiquinol form for better absorption, especially if you're over 35.
Shop on Amazon →Adaptogenic herb that reduces cortisol by approximately 30%. Supports stress resilience, sleep quality, and has mild thyroid-supportive effects. A key part of the cortisol control protocol in Chapter 2.
Shop on Amazon →Potent antioxidant, natural anti-inflammatory, and antifungal for Candida overgrowth. The recommended brand is Oreganol by North American Herb & Spice for standardized carvacrol content.
Shop on Amazon →Not supplements in the traditional sense, but two products specifically mentioned in the book for sleep and gut support.
Caffeine-free herbal tea with BC30 probiotic. Supports sleep quality and gut health simultaneously. A simple, affordable evening ritual that addresses two common PCOS concerns at once.
Shop on Amazon →For sleep support and Vitamin D activation. Take 200–400mg before bed. The glycinate form is gentler on the stomach than magnesium oxide or citrate and has better absorption.
Shop on Amazon →Your PCOS Playbook covers the research behind every supplement on this list — along with dosing guidance, what to look for on labels, and how to talk to your doctor about adding them.
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